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You should not take Plaquenil if you are allergic to Hydroxychloroquine or if you have any other allergies. Before you start taking this medication, inform your doctor about all the medications you are taking including OTC and herbal medications. This drug may make you dizzy. Do not drive or do any other activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages because they may increase your risk of liver problems while taking this medication.

This medication may make you more sensitive to the sun. You should always use sunscreen and wear protective clothing when outdoors. This medication passes into breast milk. Inform your doctor before breast-feeding. There may be a drug interaction between Plaquenil and other medications such as beta-adrenergic blockers, cyclosporine, diabetes medications, insulin, live vaccines, pimecrolimus, tacrolimus, thioridazine, etc.

Hydroquin mg Tablet should be taken with food. This will prevent you from getting an upset stomach upset. These coated tablets temporarily relieve minor aches and pains due to headache, muscular aches, minor pain of arthritis, toothache, backache, the common cold. Common side. Hydroxychloroquine Plaquenil, Hydroquin Antimalarial. Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites.

It does not work against certain types of malaria chloroquine-resistant. Autoimmun Rev. Downs SH, Black N: The feasibility of creating a checklist for the assessment of the methodological quality both of randomized and non-randomized studies of health care interventions.


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J Epidemiol Community Health. Ann Intern Med. Review Manager RevMan [computer program]. Version 4. Control Clin Trials. Stat Med. Systematic Reviews and Healthcare: meta-analysis in context. Ann Rheum Dis. Frassi M, Biasini C, Taglieti M, Daneli E: Hydroxychloroquine in pregnant patients with rheumatic disease: a case control observation of 76 treated pregnancies. Cochrane Database of Systematic Reviews.

J Perinatol. Parke A, West B: Hydroxychloroquine in pregnant patients with systemic lupus erythematosus. J Rheumatol.

What is the problem and what is known about it so far?

Am J Perinatol. Suhonen: Hydroxychloroquine administration in pregnancy. Arch Dermatol. Petri M: Systemic lupus erythematosus and pregnancy. Rheum Dis Clin North Am. Dubois's lupus erthymatosus. Results of a multidisciplinary approach. Lockshin MD: Lupus pregnancy.

Clin Rheum Dis. Am J Med. Petri M, Allbritton J: Fetal outcome of lupus pregnancy: A retrospective case-controlled study of the Hopkins lupus cohort. VI: Analysis of the interrelationship with pregnancy. J Clin Epidemiol.

Download references. Correspondence to Kirk Sperber.

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None of the authors have a financial interest in Sanofi-Winbthrop Pharmaceuticals or any other laboratory that manufactures HCQ. KS did the literature search, the statistical analysis, and wrote the paper. CH and CPC did the blinded grading and quality assessments of the studies. JA and DS wrote the manuscript. This article is published under license to BioMed Central Ltd.

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Why did the researchers do this particular study?

Sperber, K. Systematic review of hydroxychloroquine use in pregnant patients with autoimmune diseases. Pediatr Rheumatol 7, 9 Download citation. Received : 06 November Accepted : 13 May Published : 13 May Skip to main content Advertisement. Search all BMC articles Search. Abstract Objective The purpose of this study is to compare the incidence of congenital defects, spontaneous abortions, number of live births, fetal death and pre-maturity in women with autoimmune diseases taking HCQ during pregnancy.

Conclusion HCQ is not associated with any increased risk of congenital defects, spontaneous abortions, fetal death, pre-maturity and decreased numbers of live births in patients with auto-immune diseases. Background The anti-malarial drugs Hydroxychloroquine HCQ is widely used to treat various rheumatic diseases [ 1 ]. Figure 1. Full size image. Quality assessment of the articles Four of the 5 studies were observational [ 27 — 30 ] and one was a randomized placebo controlled double-blinded trial [ 31 ].

OR of congenital defects and live births Other studies have reported that HCQ is safe to use during pregnancy but had no control group [ 35 — 40 ]. Figure 2.

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Figure 3. Figure 4. Discussion Our systematic review provides evidence for the use of HCQ during pregnancy for women with auto-immune diseases. Conclusion In conclusion, based on the findings of this meta-analysis, HCQ is not associated with any increased risk of congenital defect, spontaneous abortion, fetal death, pre-maturity or decreased numbers of live births in pregnant patients with auto-immune diseases.

References 1. Article Google Scholar 5. Article PubMed Google Scholar 6.


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PubMed Google Scholar 7. Article PubMed Google Scholar Article Google Scholar Google Scholar You can also search for this author in PubMed Google Scholar. View author publications. Additional information Competing interests None of the authors have a financial interest in Sanofi-Winbthrop Pharmaceuticals or any other laboratory that manufactures HCQ. Authors' contributions KS did the literature search, the statistical analysis, and wrote the paper.