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Antimalarial agent. Inhibits tumor cell growth and metastasis and induces apoptosis in vitro. N 4 - 7-Chloroquinolinyl - N 1 , N 1 -diethylpentane-1,4-diamine diphosphate. Store under desiccating conditions.
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A study in China reported that chloroquine treatment of COVID patients had clinical and virologic benefit versus a comparison group, and chloroquine was added as a recommended antiviral for treatment of COVID in China [ 6 ]. Based upon limited in-vitro and anecdotal data, chloroquine or hydroxychloroquine are currently recommended for treatment of hospitalized COVID patients in several countries. Both chloroquine and hydroxychloroquine have known safety profiles with the main concerns being cardiotoxicity prolonged QT syndrome with prolonged use in patients with hepatic or renal dysfunction and immunosuppression but have been reportedly well-tolerated in COVID patients.
Due to higher in-vitro activity against SARS-CoV-2 and its wider availability in the United States compared with chloroquine, hydroxychloroquine has been administered to hospitalized COVID patients on an uncontrolled basis in multiple countries, including in the United States.
What are Hydroxychloroquine, Chloroquine and how much do these potential coronavirus drugs cost?
One small study reported that hydroxychloroquine alone or in combination with azithromycin reduced detection of SARS-CoV-2 RNA in upper respiratory tract specimens compared with a non-randomized control group but did not assess clinical benefit [ 7 ]. Hydroxychloroquine and azithromycin are associated with QT prolongation and caution is advised when considering these drugs in patients with chronic medical conditions e. Hydroxychloroquine is currently under investigation in clinical trials for pre-exposure or post-exposure prophylaxis of SARS-CoV-2 infection, and treatment of patients with mild, moderate, and severe COVID In the United States, several clinical trials of hydroxychloroquine for prophylaxis or treatment of SARS-CoV-2 infection are planned or will be enrolling soon.
Lopinavir-ritonavir did not show promise for treatment of hospitalized COVID patients with pneumonia in a recent clinical trial in China [ 8 ].
This trial was underpowered, and lopinavir-ritonavir is under investigation in a World Health Organization study. Several other drugs are under investigation in clinical trials or are being considered for clinical trials of prophylaxis or treatment of COVID in the United States and worldwide. Skip directly to site content Skip directly to page options Skip directly to A-Z link.
Section Navigation. Minus Related Pages. Remdesivir Remdesivir is an investigational intravenous drug with broad antiviral activity that inhibits viral replication through premature termination of RNA transcription and has in-vitro activity against SARS-CoV-2 and in-vitro and in-vivo activity against related betacoronaviruses [ ].
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The manufacturer is currently transitioning the provision of emergency access to remdesivir from individual compassionate use requests to an expanded access program. The expanded access program for the United States is under rapid development.
Other Drugs Lopinavir-ritonavir did not show promise for treatment of hospitalized COVID patients with pneumonia in a recent clinical trial in China [ 8 ]. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus nCoV in vitro.
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Cell Res. Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat Commun.